Error analysis in cross-correlation of sky maps: application to the ISW detection

Constraining cosmological parameters from measurements of the Integrated Sachs-Wolfe effect requires developing robust and accurate methods for computing statistical errors in the cross-correlation between maps. This paper presents a detailed comparison of such error estimation applied to the case of cross-correlation of Cosmic Microwave Background (CMB) and large-scale structure data. We compare theoretical models for error estimation with montecarlo simulations where both the galaxy and the CMB maps vary around a fiducial auto-correlation and cross-correlation model which agrees well with the current concordance LCDM cosmology. Our analysis compares estimators both in harmonic and configuration (or real) space, quantifies the accuracy of the error analysis and discuss the impact of partial sky survey area and the choice of input fiducial model on dark-energy constraints. We show that purely analytic approaches yield accurate errors even in surveys that cover only 10% of the sky and that parameter constraints strongly depend on the fiducial model employed. Alternatively, we discuss the advantages and limitations of error estimators that can be directly applied to data. In particular, we show that errors and covariances from the Jack-Knife method agree well with the theoretical approaches and simulations. We also introduce a novel method in real space that is computationally efficient and can be applied to real data and realistic survey geometries. Finally, we present a number of new findings and prescriptions that can be useful for analysis of real data and forecasts, and present a critical summary of the analyses done to date.Comment: submitted to MNRAS, 26 page

The use of hydrological and geoelectrical data to fix the boundary conditions of a ground water flow model: a case study

International audienceTo assess whether the hydrometric level of an artificial lake in a quarry near Milan (Italy) could be assigned as a Dirichlet boundary condition for the phreatic aquifer in a fine scale groundwater flow model, hydrological measurements of piezometric head and rainfall rate time series have been analysed by spectral and statistical methods. The piezometric head close to the quarry lake proved to be well correlated with seasonal variations in the rainfall. Furthermore, geoelectrical tomography detected no semi-permeable layer between the phreatic aquifer and the lake, so the contact between surface and ground water is good. Finally, a time-varying prescribed head condition can be applied for ground water flow modelling

Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: Implications for drug discovery

Allosteric modulators of cannabinoid receptors hold great therapeutic potential, as they do not possess intrinsic efficacy, but instead enhance or diminish the receptor's response of orthosteric ligands allowing for the tempering of cannabinoid receptor signaling without the desensitization, tolerance and dependence. Allosteric modulators of cannabinoid receptors have numerous advantages over the orthosteric ligands such as higher receptor type selectivity, probe dependence and biased signaling, so they have a great potential to separate the therapeutic benefits from side effects own of orthosteric ligands. This review aims to give an overview of the CB1 and CB2 receptor allosteric modulators highlighting the structure-activity relationship and pharmacological profile of each classes, and their future promise

Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis

Background: We have recently released the structure of a class of quinolin-2-(1H)-on-3-carboxamide derivatives and among them; the drug A2 has the highest CB2 receptor selectivity. Objective: In this work we assessed the immuno-modulatory properties of A2 in lymphocytes isolated from peripheral blood of multiple sclerosis patients and healthy donors. Methods: Cell proliferative response was measured by 3H-thymidine incorporation, cell viability and apoptosis by trypan blue, annexin V staining and western blot. Cell activation was investigated by flow cytometry and molecular pathways by western blot. Results: A2 exerted anti-proliferative effects with down-regulation of TNF-α , IL-10 and Rantes in both cell types. No relevant changes were observed in cell viability between the two cell types. In cells from healthy subjects, A2 did not induce apoptosis, inhibited the cell cycle and similarly down-regulated in CD4+T cells the markers CD69, CD25, CD49d and CD54. Indeed, A2 also inhibited the phosphorylation of Akt, NF-kB, IKKα/β, ERK and blocked the expression of Cox-2 and CB2 receptor. Published patents also describe CB2 receptor agonists like purine derivatives. Differently, in cells from patients, A2 did not affect CD49d, while potently blocked CD54 expression. A2 inhibitory effects of Akt and Cox-2 expression were confirmed, whereas unchanged level of the CB2 receptor was observed in these cells. Conclusion: We reported similar effects of A2 in both cell types; however, a different mechanism of action might be suggested in cells from patients concerning cell activation and CB2 receptor expression. Overall, these data suggest an anti-inflammatory profile of A2 with potential implication in multiple sclerosis

The clustering of the SDSS main galaxy sample - II. Mock galaxy catalogues and a measurement of the growth of structure from redshift space distortions at z=0.15

Citation: Howlett, C., Ross, A. J., Samushia, L., Percival, W. J., & Manera, M. (2015). The clustering of the SDSS main galaxy sample - II. Mock galaxy catalogues and a measurement of the growth of structure from redshift space distortions at z=0.15. Monthly Notices of the Royal Astronomical Society, 449(1), 848-866. doi:10.1093/mnras/stu2693We measure redshift space distortions in the two-point correlation function of a sample of 63 163 spectroscopically identified galaxies with z < 0.2, an epoch where there are currently only limited measurements, from the Sloan Digital Sky Survey Data Release 7 main galaxy sample (MGS). Our sample, which we denote MGS, covers 6813 deg(2) with an effective redshift z(eff) = 0.15 and is described in our companion paper (Paper I), which concentrates on baryon acoustic oscillation (BAO) measurements. In order to validate the fitting methods used in both papers, and derive errors, we create and analyse 1000 mock catalogues using a new algorithm called PICOLA to generate accurate dark matter fields. Haloes are then selected using a friends-of-friends algorithm, and populated with galaxies using a halo-occupation distribution fitted to the data. Using errors derived from these mocks, we fit a model to the monopole and quadrupole moments of the MGS correlation function. If we assume no Alcock-Paczynski (AP) effect (valid at z = 0.15 for any smooth model of the expansion history), we measure the amplitude of the velocity field, f sigma(8), at z = 0.15 to be 0.49(-0.14)(+0.15) . We also measure f sigma(8) including the AP effect. This latter measurement can be freely combined with recent cosmic microwave background results to constrain the growth index of fluctuations, gamma Assuming a background Lambda cold dark matter cosmology and combining with current BAO data, we find gamma = 0.64 +/- 0.09, which is consistent with the prediction of general relativity (gamma approximate to 0.55), though with a slight preference for higher gamma and hence models with weaker gravitational interactions

Cross-correlation of WMAP 3rd year and the SDSS DR4 galaxy survey: new evidence for Dark Energy

We cross-correlate the third-year WMAP data with galaxy samples extracted from the SDSS DR4 (SDSS4) covering 13% of the sky, increasing by a factor of 3.7 the volume sampled in previous analyses. The new measurements confirm a positive cross-correlation with higher significance (total signal-to-noise of about 4.7). The correlation as a function of angular scale is well fitted by the integrated Sachs-Wolfe (ISW) effect for LCDM flat FRW models with a cosmological constant. The combined analysis of different samples gives Omega_L=0.80-0.85$(68$0.77-0.86$ (95% CL). We find similar best fit values for Omega_L for different galaxy samples with median redshifts of z ~0.3 and z ~0.5, indicating that the data scale with redshift as predicted by the LCDM cosmology (with equation of state parameter w=-1). This agreement is not trivial, but can not yet be used to break the degeneracy constraints in the w versus Omega_L plane using only the ISW data.Comment: 5 pages, final version to be published by MNRAS Let. Minor changes with some additional clarification on error analysis don